Molecular Devices

Evaluate NMDA ligand-gated ion channels using automated electrophysiology and fast fluidic exchange

The N-Methyl-D-Aspartate (NMDA) receptor, a ligand-gated ion channel, can be challenging targets to characterize in a high-throughput setting, in part because they undergo desensitization. To obtain accurate biophysical measurements, the agonist must be removed so that the channel can again be activated.

In this poster, we demonstrate that the fast fluidics of the IonFlux™ Automated Patch Clamp System can overcome the challenge of desensitization, thus enabling high-throughput biophysical characterization of NR1/NR2B,an NMDA receptor subtype.   

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