Molecular Devices

Phenotypic assessment of toxicity
using a human hepatocyte co-culture model

Development of predictive in vitro assays for early toxicity evaluation is extremely important for improving drug development processes and reducing drug attrition rates.

In this poster, we present phenotypic assays for assessing general and mechanism-specific hepatotoxicity using the ImageXpress® Micro XLS High-Content Analysis System.

Topics include:

  • Identification of both hepatocyte islands and fibroblast areas
  • Multi-parametric evaluation of hepatocyte health
  • Toxic effects of compounds on hepatocyte islands

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