Molecular Devices

Characterization of neurotoxin modulation of Nav1.5 channels

Sodium channels are one of the primary molecular drug targets. Neurotoxins are known to be highly selective molecules against ion channels and represent a novel source of
molecules for treating ion channel-related diseases. However, despite the great potential of developing peptide toxins as drug candidates, the high-throughput electrophysiological characterization of neurotoxins has been challenging.

In this study, we show how you can evaluate the modulation of Nav1.5 channels by a number of peptide neurotoxins in a high-throughput fashion, using the IonWorks Barracuda® Plus Automated Patch Clamp System.

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