Molecular Devices

High-Throughput Assays for 3D Cancer Spheroid Cultures
 

Abstract

Three-dimensional (3D) in vitro models span the gap between two-dimensional cell cultures and whole-animal systems. By mimicking features of the in vivo environment and taking advantage of the same tools used to study cells in traditional cell culture, 3D models provide unique perspectives on the behavior of stem cells, developing tissues and organs, and tumors.

This poster presents a study whose goal was to optimize cell culture and develop new imaging and analysis methods that can be used for compound screening through assessment of multiple phenotypes in human cancer 3D models. It demonstrated concentration-response effects of selected test compounds on HTC116 cell spheroids and how the proposed methods may be used for high-content high-throughput compound screening and evaluation of anti-cancer drugs.


 

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